Case Report: Appendiceal Mucocele, an Uncommon Answer to Common Symptoms

Andrew Wilson, Thomas L. Perry, Ormond N. Panton

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A previously healthy 49-year-old man presented to the emergency department with massive epistaxis. After undergoing sphenopalatine artery ligation, his hemoglobin dropped from 135 g/L at presentation to 100 g/L post-ligation. Three weeks later, he returned to the urgent care centre with diffuse abdominal pain, fatigue, and tachycardia (heart rate of 100 beats per minute). His blood pressure was 118/84 mmHg without orthostatic change, and his abdomen was diffusely tender without localized pain or peritoneal signs. His hemoglobin was 118 g/L (135-170), his MCV 85 fL (82-98), and his stool tested positive for occult blood. Other laboratory tests were normal, including TSH.

Twenty years earlier, the patient had been diagnosed with peptic ulcer disease. More recent endoscopy showed gastritis. As a result, on this presentation, he was treated with intravenous pantoprazole (Pantoloc) in the emergency department with the provisional diagnosis of a non-life-threatening upper gastrointestinal bleed. He was discharged with a prescription for pantoprazole (Pantoloc), 40 mg per day, and an endoscopy referral.

After being discharged home, the patient returned to care three times over the following month with episodes of epigastric discomfort, tachycardia, and malaise. During each visit, he had epigastric tenderness, but no definitive diagnosis was achieved. An esophagogastroduodenoscopy (EGD) was planned, but it was not prioritized due to the negative results of the Helicobacter pylori breath test. A 24-hour urine sample was collected upon suspicion that a pheochromocytoma might explain his episodic symptoms, but the catecholamines and metabolite assays were normal. Other laboratory investigations were normal, including TSH, liver enzymes, liver function, renal/electrolytes, lipase, CEA, cortisol, CRP. Absent an anatomical diagnosis, we considered psychosomatic abdominal pain due to anxiety or stress. However, the patient was mystified, given his previous perfectly normal health and enjoyment of frequent vigorous exercise.

While he awaited endoscopy, the abdominal pain worsened, and he lost 7 kg (approximately 10%) of his body weight. An abdominal CT scan was ordered two months after the initial presentation. This revealed early mesenteric panniculitis of the jejunum and massive distension of the appendix, which protruded into the cecal lumen and contained low-density debris consistent with an appendiceal mucocele. The patient was referred to general surgery.

Prior to surgery, the EGD was normal. Colonoscopy demonstrated a mass adjacent to the ileocecal valve originating from the cecal pole, and an ultrasound also confirmed appendiceal mucocele. More than three months after first seeking medical attention, the patient underwent a laparoscopic hand-assisted right hemicolectomy. There was no evidence of carcinomatosis or pesudomyxoma peritonei. However, an inflammatory process was observed in the right upper quadrant with adhesions, which were lysed intraoperatively.

Pathological analysis of the appendiceal specimen showed a 6 by 1.5 cm low-grade mucinous neoplasm confined to the appendix, without evidence of rupture or invasion into the adjacent cecum. Thirteen lymph nodes were negative for metastatic cells. The patient was symptom-free after discharge and at six-month follow-up.


Appendiceal mucoceles are present in 0.2 to 0.3 % of all appendectomy specimens and in 8 % of appendiceal tumours.[1] A mucocele refers to an appendix that has dilated due to progressive accumulation of mucous within its lumen. They can be considered benign or malignant and can be histologically subdivided into four subtypes.[2] Mucoceles are often found incidentally on imaging or during surgery and are usually seen in patients over the age of 50.[1]

Diagnosis is confirmed by pathology. The first three histological types are considered benign, and the last is malignant. Type I appendiceal mucoceles are the result of proximal obstruction in the lumen (commonly a fecalith), causing a retention mucocele less than 1 cm in diameter with normal epithelium. If the appendix has mild dilatation and normal but hyperplastic epithelium, it is considered to be a type II mucocele (5-25 % of all appendiceal mucoceles). Type III or mucinous cystadenomas are the most common (63-84 % of all appendiceal mucoceles), and are generally less than 6 cm in diameter and lined by columnar epithelium with atypia. Type IV mucoceles (11-20% of all appendiceal mucoceles) are malignant adenocarcinomas that show severe dilatation, glandular stromal invasion, and/or peritoneal implants.[2,3]

The signs and symptoms of appendiceal mucoceles are non-specific. They include abdominal pain, mass, nausea, vomiting, and weight loss (Table 1). In one case series of 19 patients over 20 years, 11 presented clinically as appendicitis until imaging suggested a mucocele.[1] Of 135 patients identified over 25 years at the Mayo Clinic, only 65 had symptoms attributable to appendiceal pathology.[4]

Table 1. Prevalence of presenting symptoms in patients with appendiceal mucocele.

While asymptomatic patients are difficult to diagnose, the literature shows that it is symptomatic patients who are more likely to have malignant disease. Certain symptoms and findings more commonly found in patients with adenocarcinomas include abdominal pain (56 %), weight loss (77 %), abdominal mass (86 %), mucocele extravasation (83 %), and diffuse intra-peritoneal spread (95 %).[1]

While the definitive diagnosis depends on pathology, a presumptive diagnosis can be made from imaging and direct visualization. A low-attenuation mass adjacent to the cecum on CT (Figure 1) or an ultrasonographic image of a through-transmitting mass with echogenic content in the correct location is suggestive of the diagnosis.[5] Colonoscopy can reveal a soft submucosal lesion in the cecum with a central impression (appendiceal orifice) from which mucous can be visible as a “volcano sign”.[3] Pre-operative colonoscopy is used to screen for concurrent colon tumours, reportedly found in up to 29 % of cases, which can alter the surgical approach.[2] While colorectal tumours are the most common tumour associated with appendiceal mucoceles, ovarian, breast, and kidney tumours have also been linked.[6]

Figure 1. Saggital section of CT abdomen pelvis. Appendiceal mucocele (arrow) with measurements of 6×1.5cm. Max diameter 2.6cm.

The major complications from untreated appendiceal mucoceles include intestinal obstruction or bleeding, intussusception, fistulization, and volvulus. One of the most serious is the development of pseudomyxoma peritonei, the accumulation of thick gelatinous mucin containing neoplastic cells in the peritoneal cavity. This can occur through the natural progression of the neoplasm by invasion through the thinned appendiceal wall or via spontaneous or iatrogenic rupture.[2] If the tumour is malignant, the material can be generalized throughout the peritoneum rather than localized to the peri-appendicular space as seen with benign mucoceles.[3]

Surgical resection is preferred to observation due to the potential for malignant transformation and dissemination. A recent literature review recommended that an open approach is generally preferred over laparoscopy to reduce the risk of iatrogenic perforation.[2] Accordingly, if the mucocele is discovered incidentally during a laparoscopic surgery, it is recommended that the surgeon convert to an open procedure. Simple appendectomy typically results in cure if the mucocele is small and confined to the appendix. When there is evidence of perforation, positive cytology, lymph nodes, or margins on pathology, a right hemicolectomy is recommended with post-operative intraperitoneal chemotherapy and long-term follow-up.[2]

The prognosis of a benign appendiceal mucocele after treatment is good, with a 5-year survivorship of 91-100%.[3] For malignant lesions, this drops to 25% at five years, usually due to complications from pseudomyxoma peritonei.[3]

Another rare condition that might have played a role in our patient was mesenteric panniculitis, a chronic inflammatory condition of mesenteric adipose tissue of unknown etiology. A large case series of patients with CT findings of mesenteric panniculitis found that 45 of 118 (38 %) had concurrent malignancy, mostly colorectal, lymphoma, and urogenital tumours.[7] Mesenteric panniculitis can also have no identifiable cause, yet it can produce a variety of symptoms, including abdominal pain.[8] It is unclear whether our patient’s mucocele and panniculitis were linked, as the mesenteric panniculitis might have caused his symptoms, and the mucocele may have been only an incidental finding from abdominal CT.

Our patient experienced a delay of definitive diagnosis of a potentially serious condition after he presented with persistent abdominal pain. Barriers to accurate diagnosis and definitive management included a recent but apparently unrelated emergent condition (life-threatening epistaxis) and a lack of striking physical or laboratory findings. The persistent complaint of unexplained abdominal pain in an otherwise well-looking patient ultimately led to CT imaging, yielding unexpected but significant findings.

In an era when we should question the overuse of ionizing radiation, this patient’s persistent resolve that something was wrong was the catalyst to the diagnosis and treatment of uncommon conditions and to resolution of his symptoms. Sir William Osler taught, “If you listen, the patient will tell you the diagnosis.” [9] In this case, the patient gave us a needed push in the right direction.



The patient is a 49-year-old man with a history of peptic ulcer disease presenting with fatigue, malaise, and recurrent episodes of mild epigastric abdominal pain after a recent massive epistaxis requiring sphenopalatine artery ligation.


Heart rate is 100 beats/min, blood pressure is 118/84 mmHg without orthostatic change, and the abdomen is diffusely tender without localized pain or peritoneal signs. The hemoglobin is 118 g/L (135-170), the MCV 85 fL (82-98), and his stool tests positive for occult blood. Other laboratory tests are normal, including TSH, CRP, urine catecholamines, and Helicobacter pylori breath testing.

Computed tomography of the abdomen reveals massive distention of the appendix containing low-density debris, consistent with an appendiceal mucocele.


The patient is a 49-year-old man with nonspecific abdominal complaints, normocytic anemia, and a history consistent with peptic ulcer disease. After failing to respond to empiric proton-pump inhibitor therapy, he has been found to have an appendiceal mucocele on CT imaging of the abdomen.


Referred to general surgery for surgical management of the lesion, for assessment of the extent of disease, and to rule out concurrent malignancy in the colon via colonoscopy.


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  6. Rangarajan M, Palanivelu C, Kavalakat AJ, Parthasarathi R. Laparoscopic appendectomy for mucocele of the appendix: Report of 8 cases. Indian J Gastroenterol. 2006 Oct;25(5):256-7.
  7. Wilkes A, Griffin N, Dixon L, Dobbs B, Frizelle FA. Mesenteric panniculitis: a paraneoplastic phenomenon? Dis Colon Rectum. 2012 Jul;55(7):806-9.
  8. Daskalogiannaki M, Voloudaki A, Prassopoulos P et al. CT evaluation of mesenteric panniculitis: prevalence and associated diseases. Am J Roentgenol. 2000 Feb;174(2):427-31.
  9. Bryan CS. Osler: Inspirations from a great physician. Oxford University Press; 2003.

Wilson A, Perry TL, Panton ON. Case Report: Appendiceal Mucocele, an Uncommon Answer to Common Symptoms. UBCMJ. 2015; 6(2):23-25.